The Role of Matrix Protein 2 Ectodomain in the Development of Universal Influenza Vaccines
Identifieur interne : 000038 ( Main/Exploration ); précédent : 000037; suivant : 000039The Role of Matrix Protein 2 Ectodomain in the Development of Universal Influenza Vaccines
Auteurs : Xavier Saelens [Belgique]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2019.
Abstract
The influenza A virus matrix protein 2 ectodomain (M2e) is a universal influenza A vaccine candidate. Numerous studies in laboratory mice, but very few in natural influenza A virus hosts, have demonstrated that M2e-based vaccines can provide protection against any influenza A virus challenge. M2e-based immunity is largely accomplished by IgG and early stage clinical studies have demonstrated that the vaccine is safe. Yet M2e is considered a difficult target to develop as a vaccine: it does not offer sterilizing immunity and its mode of action relies on Fcγ receptor-mediated effector mechanisms, most likely in concert with alveolar macrophages. In a human challenge study with an H3N2 virus, treatment with a monoclonal M2e-specific human IgG was associated with a faster recovery compared to placebo treatment. If the universal influenza vaccine field incorporates this antigen into next generation vaccines, M2e could prove its merit when the next influenza pandemic strikes.
Url:
DOI: 10.1093/infdis/jiz003
PubMed: 30715367
PubMed Central: 6452325
Affiliations:
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Numerous studies in laboratory mice, but very few in natural influenza A virus hosts, have demonstrated that M2e-based vaccines can provide protection against any influenza A virus challenge. M2e-based immunity is largely accomplished by IgG and early stage clinical studies have demonstrated that the vaccine is safe. Yet M2e is considered a difficult target to develop as a vaccine: it does not offer sterilizing immunity and its mode of action relies on Fcγ receptor-mediated effector mechanisms, most likely in concert with alveolar macrophages. In a human challenge study with an H3N2 virus, treatment with a monoclonal M2e-specific human IgG was associated with a faster recovery compared to placebo treatment. If the universal influenza vaccine field incorporates this antigen into next generation vaccines, M2e could prove its merit when the next influenza pandemic strikes.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lamb, Ra" uniqKey="Lamb R">RA Lamb</name></author><author><name sortKey="Lai, Cj" uniqKey="Lai C">CJ Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pinto, Lh" uniqKey="Pinto L">LH Pinto</name></author><author><name sortKey="Holsinger, Lj" uniqKey="Holsinger L">LJ Holsinger</name></author><author><name sortKey="Lamb, Ra" uniqKey="Lamb R">RA Lamb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stauffer, S" uniqKey="Stauffer S">S Stauffer</name></author><author><name sortKey="Feng, Y" uniqKey="Feng Y">Y Feng</name></author><author><name sortKey="Nebioglu, F" uniqKey="Nebioglu F">F Nebioglu</name></author><author><name sortKey="Heilig, R" 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flamande</li></region><settlement><li>Gand</li></settlement><orgName><li>Université de Gand</li></orgName></list><tree><country name="Belgique"><region name="Région flamande"><name sortKey="Saelens, Xavier" sort="Saelens, Xavier" uniqKey="Saelens X" first="Xavier" last="Saelens">Xavier Saelens</name></region><name sortKey="Saelens, Xavier" sort="Saelens, Xavier" uniqKey="Saelens X" first="Xavier" last="Saelens">Xavier Saelens</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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